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Evidence found and GRADE certainty

1,679 questions · 1,720 findings · 335 reviews · Headline outcomes only

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No studies found 192 · 11.2%GRADE not reported 75 · 4.4%Very low 526 · 30.6%Low 504 · 29.3%Moderate 305 · 17.7%High 118 · 6.9%

Levonorgestrel vs Yuzpe

Menses ‐ early · women seeking emergency contraception

Levonorgestrel showed no clear difference in menses ‐ Early compared with yuzpe (low certainty).

1 finding from 1 review

Corticosteroids vs control

Early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28; day 60; and in hospital · adults with acute respiratory distress syndrome

Corticosteroids showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: day 14; day 28;… compared with control (low certainty).

1 finding from 1 review

Statins vs control

Early all‐cause mortality (≤ 3 months) Reported at: 28 days; 60 days; and during hospital stay · adults with acute respiratory distress syndrome

Statins showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: 60 days; and… compared with control (moderate certainty).

1 finding from 1 review

Beta‐agonist vs control

Early all‐cause mortality (≤ 3 months) Reported at: 28 days; 60 days; and during hospital stay · adults with acute respiratory distress syndrome

Beta‐agonist showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: 28 days; 60… compared with control (moderate certainty).

1 finding from 1 review

Surfactants vs control

Early all‐cause mortality (≤ 3 months) Reported at: 28 days; and 90 days. Time point not reported in 4 studies · adults with acute respiratory distress syndrome

It is very uncertain whether surfactants changes early all‐cause mortality (≤ 3 months) Reported at: 28 days; and 90… compared with control (very low certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Both one‐to‐one and group counselling · developing countries

Community health educational one‐to‐one and group and both… probably leads to lower early neonatal mortality ‐ Both one‐to‐one and group counselling compared with control (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during ANC period only · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during ANC period only compared with control (very low certainty).

1 finding from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during PNC period only · developing countries

Community health educational ANC period and PNC period and both… showed no clear difference in early neonatal mortality ‐ Education provided during PNC period only compared with control (moderate certainty).

1 finding from 1 review

Community health educational ANC period and PNC period and both periods (subgroup) vs control

Early neonatal mortality ‐ Education provided during both ANC and PNC periods · developing countries

It is very uncertain whether community health educational ANC period and PNC period and both… changes early neonatal mortality ‐ Education provided during both ANC and… compared with control (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers and family members · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers and family… compared with control (very low certainty).

1 finding from 1 review

Community health educational intervention for family members and mothers and for mothers only (subgroup) vs control

Early neonatal mortality ‐ Intervention given to mothers only · developing countries

It is very uncertain whether community health educational intervention for family members and… changes early neonatal mortality ‐ Intervention given to mothers only compared with control (very low certainty).

1 finding from 1 review

Community health educational one‐to‐one and group and both counselling (subgroup) vs control

Early neonatal mortality ‐ Group counselling · developing countries

Community health educational one‐to‐one and group and both… may leads to lower early neonatal mortality ‐ Group counselling compared with control (low certainty).

1 finding from 1 review