Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

900 questions · 932 findings · 149 reviews

No studies found 215 · 23.1%GRADE not reported 65 · 7%Very low 234 · 25.1%Low 256 · 27.5%Moderate 134 · 14.4%High 28 · 3%

HFNC vs continuous positive airway pressure (CPAP)

Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in death (before hospital discharge) or BPD(supplemental… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in BPD (supplemental oxygen/respiratory support at 36 weeks'… compared with continuous positive airway pressure (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support

Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).

1 finding from 1 review

Individual tailored vs continuous tapered dexamethasone regimen

Death or cerebral palsy at 1 to 3 years · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or cerebral palsy at 1 to 3 years compared with continuous tapered dexamethasone regimen (moderate certainty).

1 finding from 1 review

Individual tailored vs continuous tapered dexamethasone regimen

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or abnormal neurodevelopmental outcome (various definitions) compared with continuous tapered dexamethasone regimen (low certainty).

1 finding from 1 review

Pulse vs continuous dexamethasone therapy

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants at risk for bronchopulmonary dysplasia

Pulse may leads to higher death or bronchopulmonary dysplasia at 36 weeks' PMA compared with continuous dexamethasone therapy (low certainty).

1 finding from 1 review

Pulse vs continuous dexamethasone therapy

Death or abnormal neurodevelopmental outcome (various definitions) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether pulse changes death or abnormal neurodevelopmental outcome (various definitions) compared with continuous dexamethasone therapy (very low certainty).

1 finding from 1 review

Individual tailored vs continuous tapered dexamethasone regimen

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants at risk for bronchopulmonary dysplasia

Individual tailored showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks PMA compared with continuous tapered dexamethasone regimen (low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Treatment failure · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes treatment failure compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Duration of any form of respiratory support (any form of non‐invasive respiratory support with or without supplemental oxygen) · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))
1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Adverse events ‐ nasal trauma · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes adverse events ‐ nasal trauma compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

HFNC vs continuous positive airway pressure (CPAP)

Adverse events ‐ abdominal overdistention · respiratory support in term infants (infants ≥ 37 weeks gestational age to the end of the neonatal period (up to 1 month postnatal age))

It is very uncertain whether summary of findings table ‐ High flow nasal cannula (HFNC) changes adverse events ‐ abdominal overdistention compared with continuous positive airway pressure (CPAP) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Intermittent PEG‐asparaginase treatment (8 doses, 1000 IU/m2, IM) vs continuous PEG‐asparaginase treatment (15 doses, 1000 IU/m2, IM)

Overall survival ‐ not reported · children and adolescents (< 18 years of age) with first‐line ALL

The review found no eligible studies for this question.

1 finding from 1 review