Intervention not reported
Number commencing naltrexone maintenance treatment ‐ Clonidine comparison · patients with opioid withdrawal
The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Clonidine… (moderate certainty).
1 finding from 1 review
Intervention not reported
Number commencing naltrexone maintenance treatment ‐ Buprenorphine comparison · patients with opioid withdrawal
The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Buprenorphine… (moderate certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Tapered methadone comparison · patients with opioid withdrawal
The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (low certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Clonidine comparison · patients with opioid withdrawal
The intervention probably leads to higher retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).
1 finding from 1 review
Intervention not reported
Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Buprenorphine comparison · patients with opioid withdrawal
The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).
1 finding from 1 review
Continuous abstinence from cocaine (number of participants who had achieved and maintained abstinence for at least three weeks at the end of treatment) · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Point abstinence (number of participants who were abstinent at the end of the treatment) · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acceptability ‐ total dropouts · patients with the treatment of cocaine dependence
It is very uncertain whether summary of findings table – disulfiram changes dropout for any reason (number of participants who did not complete… compared with naltrexone (very low certainty).
1 finding from 1 review
Dropouts due to adverse events · patients with the treatment of cocaine dependence
It is very uncertain whether summary of findings table – disulfiram changes dropout due to adverse events (number of participants who did not… compared with naltrexone (very low certainty).
1 finding from 1 review
RR 0.5 [0.07, 3.55]
1 study · 8 participants
Very low
Adverse events as N of participants with at least one adverse event objective · patients with the treatment of cocaine dependence
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of cocaine use (mean number of days or weeks of cocaine use at the end of treatment) · patients with the treatment of cocaine dependence
1 finding from 1 review
Amount of cocaine use (mean weight of cocaine used or money spent on cocaine at the end of treatment) · patients with the treatment of cocaine dependence
1 finding from 1 review
Relapse: return to any drinking at end of treatment · alcohol use disorder
It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with naltrexone (very low certainty).
1 finding from 1 review
Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder
It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with ≥ 1 adverse event at end… compared with naltrexone (very low certainty).
1 finding from 1 review
Dropout · alcohol use disorder
It is very uncertain whether summary of findings table ‐ Baclofen changes dropouts at end of treatment compared with naltrexone (very low certainty).
1 finding from 1 review