Findings

What do systematic reviews say?

63 questions · 65 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 40 · 61.5%GRADE not reported 1 · 1.5%Very low 9 · 13.8%Low 11 · 16.9%Moderate 4 · 6.2%High 0 · 0%

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
RR 2.66
1 study · 83 participants
Very low

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Haemoglobin status · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 83 participants
Very low

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

Change in BMI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

Time to next exacerbation · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

Adverse events · adults and children with cystic fibrosis

Summary of findings: oral vitamin E supplementation showed no clear difference in adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
OR 1 [0.13, 7.94]
1 study · 38 participants
Low

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral vitamin E supplementation vs placebo or no treatment

Quality of life · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Serious adverse events · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Mortality due to any cause · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Quality of life · children with sickle cell anaemia and microalbuminuria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Angiotensin‐converting enzyme inhibitors vs vitamin C

Reduction or prevention of kidney disease progression · children with sickle cell anaemia and microalbuminuria

1 finding from 1 review

Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 170 participants
Very low

Intervention not reported

QoL: CFQ‐R · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

QoL: CFQoL · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse events · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

PIVKA II levels: change in PIVKA II (ng/mL) · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Uncarboxylated osteocalcin: change in carboxylation of osteocalcin level (% Glu‐OC) · people with cystic fibrosis

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Very low

Intervention not reported

Time to cessation of bleeding · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Bone mineral density: lumbar spine z score · people with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin K supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Growth and nutritional status:z‐score for height · children and adults with CF

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intervention not reported

Mortality · children and adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found