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Evidence found and GRADE certainty

94 questions · 95 findings · 11 reviews · Pregnancy and Childbirth

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No studies found 4 · 4.2%GRADE not reported 10 · 10.5%Very low 18 · 18.9%Low 36 · 37.9%Moderate 15 · 15.8%High 12 · 12.6%

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Low birthweight · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Participants with at least some Side Effects · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal clinical malaria or other infection in pregnancy · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal clinical malaria or other infection in pregnancy compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Birthweight (g) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in birthweight (g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Gestational age (preterm birth < 37 weeks) · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in premature birth (less than 37 weeks of gestation) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Neonatal mortality · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes neonatal death (within 28 days after delivery) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal death · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… led to lower maternal death (death while pregnant or within 42 days of… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes; GRADE not reported.

1 finding from 1 review