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Evidence found and GRADE certainty

45 questions · 46 findings · 6 reviews · Vascular

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No studies found 10 · 21.7%GRADE not reported 0 · 0%Very low 2 · 4.3%Low 18 · 39.1%Moderate 15 · 32.6%High 1 · 2.2%

Direct thrombin inhibitors vs low molecular weight heparin

Major VTE events bilateral ascending venography1 · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events bilateral ascending venography1 compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

All‐cause Mortality events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors probably leads to higher all‐cause Mortality events compared with low molecular weight heparins (moderate certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Total Bleeding events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in total Bleeding events compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

ALT >3 times the upper normal limit · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors may leads to lower ALT >3 times the upper normal limit compared with low molecular weight heparins (low certainty).

1 finding from 1 review