Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

61 questions · 61 findings · 6 reviews · Epilepsy

No studies found 14 · 23%GRADE not reported 0 · 0%Very low 8 · 13.1%Low 29 · 47.5%Moderate 8 · 13.1%High 2 · 3.3%

Topiramate vs valproate

Proportion of responders (at least 50% seizure frequency reduction in PGTCS) · people with juvenile myoclonic epilepsy

It is very uncertain whether topiramate changes proportion of responders (at least 50% seizure frequency reduction… compared with valproate (very low certainty).

1 finding from 1 review

Topiramate vs valproate

Seizure freedom · people with juvenile myoclonic epilepsy

It is very uncertain whether topiramate changes number of participants who were seizure‐free compared with valproate (very low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Seizure freedom · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture showed no clear difference in seizure freedom ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

50% or greater reduction in seizure frequency · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture may leads to higher 50% or greater reduction in seizure frequency ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…
1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Frequency of adverse effects ‐ dizziness ( · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture showed no clear difference in frequency of adverse effects ‐ dizziness ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Frequency of adverse effects ‐ malaise ( · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture showed no clear difference in frequency of adverse effects ‐ malaise ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Nausea · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture showed no clear difference in frequency of adverse effects ‐ nausea ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture vs valproate

Frequency of adverse effects ‐ sleepiness ( · participants with epilepsy (one included study only recruited children with absence epilepsy while another included study recruited both…

Summary of findings: needle acupuncture showed no clear difference in frequency of adverse effects ‐ sleepiness ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: catgut implantation at acupoints vs valproate

50% or greater reduction in seizure frequency · participants with generalised epilepsy

Summary of findings: catgut implantation at acupoints showed no clear difference in 50% or greater reduction in seizure frequency ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: catgut implantation at acupoints vs valproate

Frequency of adverse effects ‐ dizziness ( · participants with generalised epilepsy

Summary of findings: catgut implantation at acupoints showed no clear difference in frequency of adverse effects ‐ dizziness ( compared with valproate (low certainty).

1 finding from 1 review

Summary of findings: catgut implantation at acupoints vs valproate

Frequency of adverse effects ‐ malaise ( · participants with generalised epilepsy

Summary of findings: catgut implantation at acupoints showed no clear difference in frequency of adverse effects ‐ malaise ( compared with valproate (low certainty).

1 finding from 1 review