Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 65 findings · 10 reviews

No studies found 8 · 12.3%GRADE not reported 2 · 3.1%Very low 27 · 41.5%Low 19 · 29.2%Moderate 9 · 13.8%High 0 · 0%

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Efficacy as a dichotomous outcome · patients with cancer and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRIs) changes efficacy as a dichotomous outcome compared with tricyclic antidepressants (TCAs) (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Acceptability ‐ total dropouts · patients with cancer and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRIs) changes dropouts due to any cause (acceptability) compared with tricyclic antidepressants (TCAs) (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Hospitalization · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of hospitalization compared with hospital intervention alone (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of ICU admission compared with hospital intervention alone (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

SDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention alone (low certainty).

1 finding from 1 review

Psychological therapies vs tricyclic antidepressants (TCAs)

Short‐term improvement Scale used (range; lower is better): Clinical Global Impression (1 to 7) Agoraphobic Cognitions Questionnaire (1 to 70) Panic Disorder Severity Scale (0 to 28) Brief Scale for Anxiety (0 to 60) · adults with panic disorder
1 finding from 1 review

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review