Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 222 findings · 37 reviews · Pain, Palliative and Supportive Care

No studies found 32 · 14.4%GRADE not reported 12 · 5.4%Very low 74 · 33.3%Low 56 · 25.2%Moderate 42 · 18.9%High 6 · 2.7%

CBT vs TAU

Pain intensity (number of people with ≥ 30% improvement) (Higher scores indicate improvement) · chronic pain (excluding headache) in adults

CBT probably leads to higher pain intensity (number of people with ≥ 30% improvement) (Higher… compared with TAU (post‐treatment) (moderate certainty).

1 finding from 1 review

CBT vs TAU

Pain intensity (number of people with ≥ 50% improvement) · chronic pain (excluding headache) in adults

CBT may leads to higher pain intensity (number of people with ≥ 50% improvement) (Higher… compared with TAU (post‐treatment) (low certainty).

2 findings from 1 review

CR oxycodone vs IR oxycodone

Pain intensity (mean across treatment or at end of treatment; length of treatment varied across trials; various pain intensity scales; SMD) · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes pain intensity (mean across treatment or at end of treatment; length… compared with IR oxycodone (very low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with cancer‐related pain

CR oxycodone may leads to higher pain intensity (various pain intensity scales; SMD) compared with CR morphine (low certainty).

1 finding from 1 review

Hydromorphone vs oxycodone

Participant‐reported pain intensity VAS (0‐10, lower score = less pain) · people with moderate to severe cancer pain
1 finding from 1 review

Hydromorphone vs fentanyl

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with moderate to severe cancer pain
1 finding from 1 review

Hydromorphone vs morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with moderate to severe cancer pain
1 finding from 1 review

Active stimulation vs Placebo (sham/placebo device)

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults with chronic pain
3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Participant‐reported pain relief of 50% or greater · adults with chronic pain

It is very uncertain whether active stimulation + other intervention changes pain intensity. Proportion with ≥ 50% pain relief. compared with other intervention alone (very low certainty).

1 finding from 1 review

Active stimulation + other intervention vs other intervention alone

Pain intensity (number of people with ≥ 50% improvement) · adults with chronic pain

Active stimulation + other intervention may leads to higher pain intensity. Proportion with ≥50% pain relief. compared with other intervention alone (low certainty).

2 findings from 1 review