Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

140 questions · 147 findings · 26 reviews · Emergency and Critical Care

No studies found 24 · 16.3%GRADE not reported 2 · 1.4%Very low 56 · 38.1%Low 43 · 29.3%Moderate 12 · 8.2%High 10 · 6.8%

Automated monitoring systems vs usual care

Time to initiation of antimicrobial therapy (Time to initiation starts at the time of admission) · people admitted to intensive care units

It is very uncertain whether automated monitoring systems changes time to initiation of antimicrobial therapy (Time to initiation… compared with standard care (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU

It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU

It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Myocardial infarction · adults admitted to the ICU

It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Stroke · adults admitted to the ICU

It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU

It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Incidence of severe hypoxaemia (SpO2 < 80%) · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of severe hypoxaemia (SpO2 < 80%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Hypoxaemia · people requiring tracheal intubation

Oxygenation showed no clear difference in incidence of hypoxaemia (SpO2 < 93%) compared with no oxygenation during the apnoeic period preceding intubation (low certainty).

1 finding from 1 review

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

First‐pass success of cannulation · people requiring tracheal intubation

Oxygenation showed no clear difference in first pass success rate compared with no oxygenation during the apnoeic period preceding intubation (moderate certainty).

1 finding from 1 review