Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 63 findings · 5 reviews · Pregnancy and Childbirth

No studies found 12 · 19%GRADE not reported 7 · 11.1%Very low 13 · 20.6%Low 22 · 34.9%Moderate 9 · 14.3%High 0 · 0%

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Apgar score less than 7 at 5 minutes · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline showed no clear difference in 5‐minute Apgar score < 7 compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Low umbilical artery pH (< 7.2 or as defined by trial authors) · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline showed no clear difference in umbilical artery pH < 7.2 compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Abnormal FHR as defined by trial authors (FHR tracing not improved) · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline probably leads to lower FHR tracing not improved compared with no tocolytic agent, whilst awaiting emergency delivery (moderate certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Caesarean section · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate probably leads to higher caesarean delivery compared with emergency delivery (moderate certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Apgar score less than 7 at 5 minutes · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in 5‐minute Apgar score < 7 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV fenoterol bromhydrate vs emergency delivery

Umbilical artery pH < 7.1 · women with a non‐reassuring fetal heart trace during labour but without uterine tachysystole

Summary of findings for IV fenoterol bromhydrate showed no clear difference in umbilical artery pH < 7.1 compared with emergency delivery (low certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs diazepam

Surgical assessment/satisfaction score = 1 or 2 (Technically successful procedure as defined by trial authors) · health problem or population

Summary of findings table ‐ Remifentanil may leads to higher surgical assessment/satisfaction score = 1 or 2 (Technically… compared with diazepam (low certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs diazepam

Maternal OAA score (observer assessment of alertness/sedation) < 4 (Maternal sedation measured using sedation scores as defined by authors) · health problem or population

Summary of findings table ‐ Remifentanil may leads to lower maternal OAA score (observer assessment of alertness/sedation) < 4… compared with diazepam (low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal anaemia · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal anaemia compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Maternal vitamin B12 deficiency · pregnant women

It is very uncertain whether summary of findings table ‐ Vitamin B12 supplementation changes maternal vitamin B12 deficiency compared with placebo/no vitamin B12 supplementation (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Vitamin B12 supplementation vs no supplementation or placebo

Low birthweight · pregnant women

Summary of findings table ‐ Vitamin B12 supplementation showed no clear difference in low birthweight (< 2500 g) compared with placebo/no vitamin B12 supplementation (low certainty).

1 finding from 1 review