The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
It is very uncertain whether summary of findings 2: PLD alone changes overall severe adverse events (grade > 3) compared with other conventional chemotherapy (very low certainty).
It is very uncertain whether summary of findings 2: PLD alone changes anaemia (grade ≥ 3) compared with other conventional chemotherapy (very low certainty).
It is very uncertain whether summary of findings 2: PLD alone changes hand‐foot syndrome (grade ≥ 3) compared with other conventional chemotherapy (very low certainty).
It is very uncertain whether summary of findings 2: PLD alone changes neurological (grade ≥ 3) compared with other conventional chemotherapy (very low certainty).
Summary of findings 2: PLD alone showed no clear difference in overall survival (OS) compared with other conventional chemotherapy (moderate certainty).
It is very uncertain whether summary of findings 2: PLD alone changes progression‐free survival (PFS) compared with other conventional chemotherapy (very low certainty).
Summary of findings: Counselling showed no clear difference in mean GI symptom scores (lower is better) compared with no intervention (low certainty).
The review found no eligible studies for this question.
Summary of findings: Counselling may leads to lower diarrhoea (grade 2+) compared with no intervention (low certainty).
It is very uncertain whether summary of findings: Counselling changes QOL scores (5‐point VAS; lower is better) compared with no intervention (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Summary of findings: Misoprostol showed no clear difference in acute and late GI toxicity (grade 2+) compared with placebo (low certainty).
It is very uncertain whether summary of findings: Misoprostol changes diarrhoea (grade 2+) compared with placebo (very low certainty).
The review found no eligible studies for this question.
Summary of findings: antibiotics leads to lower all cause mortality compared with placebo or no intervention (high certainty).
Summary of findings: antibiotics probably leads to lower febrile patients and episodes compared with placebo or no intervention (moderate certainty).