Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

171 questions · 175 findings · 13 reviews · Haematology

No studies found 43 · 24.6%GRADE not reported 18 · 10.3%Very low 40 · 22.9%Low 40 · 22.9%Moderate 26 · 14.9%High 8 · 4.6%

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Mortality from all causes up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Number of platelet transfusions per participant up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Mycophenolate mofetil vs methotrexate

Prevention of acute GVHD grade II to IV · people receiving allogeneic hematopoietic stem cell transplantation

It is very uncertain whether mycophenolate mofetil changes prevention of acute GVHD grade II to IV compared with methotrexate (very low certainty).

1 finding from 1 review

Mycophenolate mofetil vs methotrexate

Incidence of narcotic use for pain control · people receiving allogeneic hematopoietic stem cell transplantation

Mycophenolate mofetil may leads to lower incidence of narcotic use for pain control compared with methotrexate (low certainty).

1 finding from 1 review

Ursodeoxycholic acid vs placebo or no treatment

Incidence of hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

Summary of findings: Ursodeoxycholic acid may leads to lower incidence of hepatic veno‐occlusive disease ( compared with placebo or no treatment (low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no treatment

Incidence of hepatic veno‐occlusive disease ( · People undergoing stem cell transplant with malignant diseases

It is very uncertain whether summary of findings: Low molecular weight heparin changes incidence of hepatic veno‐occlusive disease ( compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Low molecular weight heparin vs placebo or no treatment

Frequency of adverse events ( · People undergoing stem cell transplant with malignant diseases

It is very uncertain whether summary of findings: Low molecular weight heparin changes frequency of adverse events ( compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Summary of findings: Defibrotide vs no treatment

Incidence of hepatic veno‐occlusive disease ( · Children undergoing stem cell transplant with malignant and non‐malignant diseases and risk factors for hepatic veno‐occlusive disease

Summary of findings: Defibrotide showed no clear difference in incidence of hepatic veno‐occlusive disease ( compared with no treatment (low certainty).

1 finding from 1 review