Cochrane · systematic review · CD010280
Mycophenolate mofetil versus methotrexate for prevention of graft‐versus‐host disease in people receiving allogeneic hematopoietic stem cell transplantation
Kharfan‐Dabaja, M, Mhaskar, R, Reljic, T, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 12.5%Low 7 · 87.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Mycophenolate mofetil versus methotrexate for prevention of graft‐versus‐host disease in people receiving allogeneic hematopoietic stem cell transplantation
Population: people receiving allogeneic hematopoietic stem cell transplantation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Mycophenolate mofetil vs methotrexate | HR 0.73 [0.45, 1.17] | 2 studies · 129 participants | Low Downgraded: risk of bias, publication bias |
Prevention of acute GVHD grade II to IV Mycophenolate mofetil vs methotrexate | RR 1.25 [0.75, 2.09] | 3 studies · 174 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Incidence of relapse Mycophenolate mofetil vs methotrexate | RR 0.84 [0.52, 1.38] | 2 studies · 129 participants | Low Downgraded: risk of bias, publication bias |
Nonrelapse mortality Mycophenolate mofetil vs methotrexate | RR 1.21 [0.62, 2.36] | 1 study · 89 participants | Low Downgraded: risk of bias |
Prevention of chronic GVHD Mycophenolate mofetil vs methotrexate | RR 0.92 [0.65, 1.3] | 2 studies · 129 participants | Low Downgraded: risk of bias, publication bias |
Incidence of severe mucositis Mycophenolate mofetil vs methotrexate | RR 0.48 [0.32, 0.73] | 3 studies · 174 participants | Low Downgraded: risk of bias, publication bias |
Use of total parenteral nutrition Mycophenolate mofetil vs methotrexate | RR 0.48 [0.26, 0.91] | 2 studies · 129 participants | Low Downgraded: risk of bias, publication bias |
Incidence of narcotic use for pain control Mycophenolate mofetil vs methotrexate | RR 0.76 [0.63, 0.91] | 2 studies · 129 participants | Low Downgraded: risk of bias, publication bias |