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Evidence found and GRADE certainty

260 questions · 357 findings · 37 reviews · Dental caries

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No studies found 24 · 6.7%GRADE not reported 257 · 72%Very low 37 · 10.4%Low 27 · 7.6%Moderate 4 · 1.1%High 8 · 2.2%

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (proportion of bleeding sites) compared with interdental brushing plus toothbrushing (very low certainty).

2 findings from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes plaque compared with toothbrushing alone (very low certainty).

1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Mineral trioxide aggregate (MTA)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
  • Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
    mean 22 months
    Assessed pain, soft tissue pathology, mobility, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
    1 study · 130 participants
    GRADE not reported

Fluoride-free nano-hydroxyapatite (nHA) dentifrice/paste vs Sodium fluoride (control) toothpaste

Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients

Under demineralizing conditions, nHA allowed significantly more enamel demineralization than NaF (MD 1625, 95% CI 553 to 2697; very low certainty).

2 findings from 1 review

Visual classification: ERK (Ekstrand-Ricketts-Kidd system) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Visual classification: ERK (Ekstrand-Ricketts-Kidd system) vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Sensitivity for detection of enamel caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Ferric sulphate (FS)/zinc oxide and eugenol (ZOE) pulpotomy vs Sedanol (ZOE) pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate (FS)/zinc oxide and eugenol (ZOE) pulpotomy showed no clear difference in radiological failure compared with sedanol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

Electrical conductance (e.g. electronic caries monitor, ECM) vs Reference standard: histology or enhanced visual-tactile examination

Outcome not reported · Adults presenting asymptomatically or suspected of having root caries (in vivo); extracted teeth of adults (in vitro)

The review found no eligible studies for this question.

1 finding from 1 review
  • Tests to detect and inform the diagnosis of root caries 2020 · Cochrane All outcomes
    Electrical conductance was a pre-specified eligible index test but no diagnostic test accuracy study of electrical conductance was included. A study evaluating the electronic caries monitor (ECM) (Wicht 2002) was…
    0 studies
    No studies found

Prefabricated zirconia crowns (e.g., NuSmile, Zirkiz, Kinder Krown) vs Other crowns/restorations (stainless steel crowns, pre-veneered SSC, resin composite strip crowns, glass-fiber composite crowns)

Recurrent caries (crowns free of recurrent caries) · Children with primary (deciduous) teeth requiring full-coverage crown restoration

Recurrent caries did not differ between zirconia crowns and other restorations at 6 months (RR 1.00, 95% CI 0.97 to 1.03; 2 studies; not GRADE-rated).

2 findings from 1 review

Prefabricated zirconia crowns (e.g., NuSmile, Zirkiz, Kinder Krown) vs Other crowns/restorations (stainless steel crowns, pre-veneered SSC, resin composite strip crowns, glass-fiber composite crowns)

Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration

Zirconia crowns showed no significant difference in crown retention versus other restorations at 6 months (RR 1.02, 95% CI 0.94 to 1.11; 3 studies; not GRADE-rated).

2 findings from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review