Findings

What do systematic reviews say?

45 questions · 45 findings · 5 reviews

No studies found 7 · 15.6%GRADE not reported 1 · 2.2%Very low 1 · 2.2%Low 18 · 40%Moderate 16 · 35.6%High 2 · 4.4%

Rebleeding · patients with acute peptic ulcer bleeding

High showed no clear difference in rebleeding compared with non‐high (medium or low) dose regimen (low certainty).

1 finding from 1 review

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
RR 1.27 [0.96, 1.67]
13 studies · 1716 participants
Low

Surgery · patients with acute peptic ulcer bleeding

High showed no clear difference in surgery compared with non‐high (medium or low) dose regimen (low certainty).

1 finding from 1 review

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
RR 1.33 [0.63, 2.77]
9 studies · 1270 participants
Low

Further EHT · patients with acute peptic ulcer bleeding

High showed no clear difference in further EHT compared with non‐high (medium or low) dose regimen (low certainty).

1 finding from 1 review

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
RR 1.39 [0.88, 2.18]
6 studies · 902 participants
Low

Length of hospital stay · patients with acute peptic ulcer bleeding

1 finding from 1 review

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1069 participants
Moderate

Blood transfusion · patients with acute peptic ulcer bleeding

1 finding from 1 review

Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1069 participants
Moderate