Cochrane · systematic review · CD007999
Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding
Neumann, I, Letelier, LM, Rada, G, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 2 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
High compared to non‐high (medium or low) dose regimen for acute peptic ulcer bleeding
Population: patients with acute peptic ulcer bleeding
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality High vs non‐high (medium or low) dose regimen | RR 0.85 [0.47, 1.54] | 12 studies · 1667 participants | Low Downgraded: risk of bias |
Rebleeding High vs non‐high (medium or low) dose regimen | RR 1.27 [0.96, 1.67] | 13 studies · 1716 participants | Low Downgraded: risk of bias |
Surgery High vs non‐high (medium or low) dose regimen | RR 1.33 [0.63, 2.77] | 9 studies · 1270 participants | Low Downgraded: risk of bias |
Further EHT High vs non‐high (medium or low) dose regimen | RR 1.39 [0.88, 2.18] | 6 studies · 902 participants | Low Downgraded: risk of bias |
Length of hospital stay High vs non‐high (medium or low) dose regimen | no estimate extracted | 6 studies · 1069 participants | Moderate Downgraded: risk of bias |
Blood transfusions High vs non‐high (medium or low) dose regimen | no estimate extracted | 6 studies · 1069 participants | Moderate Downgraded: risk of bias |