Findings

What do systematic reviews say?

62 questions · 63 findings · 5 reviews · Pain, Palliative and Supportive Care

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No studies found 3 · 4.8%GRADE not reported 2 · 3.2%Very low 12 · 19%Low 3 · 4.8%Moderate 19 · 30.2%High 24 · 38.1%

Pregabalin 300 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 3384 participants
High

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 30% or greater · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 789 participants
Moderate

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1360 participants
Moderate

Pregabalin 600 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 537 participants
Moderate

Pregabalin 600 mg vs placebo

Lack of efficacy withdrawal · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 879 participants
High

Pregabalin 600 mg vs placebo

Somnolence · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1501 participants
Moderate

Pregabalin 600 mg vs placebo

Dizziness · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1885 participants
Moderate

Pregabalin 600 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with painful diabetic neuropathy

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1669 participants
High

Pregabalin 300 mg vs placebo

Patient Global Impression of Change much or very much improved · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 568 participants
Low

Pregabalin 300 mg vs placebo

Lack of efficacy withdrawal · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
High

Pregabalin 300 mg vs placebo

Somnolence · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Dizziness · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
Moderate

Pregabalin 300 mg vs placebo

Withdrawals due to adverse events · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 933 participants
High

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 30% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 537 participants
Moderate

Pregabalin 600 mg vs placebo

Participant‐reported pain relief of 50% or greater · adults with moderate or severe pain associated with postherpetic neuralgia

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 732 participants
Moderate

Pregabalin 300 mg or 600 mg vs placebo

Risk for at least one adverse event per patient · adults with moderate or severe neuropathic pain

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3697 participants
High

Pregabalin 300 mg or 600 mg vs placebo

Serious AE · adults with moderate or severe neuropathic pain

1 finding from 1 review

Pregabalin for neuropathic pain in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
17 studies · 4112 participants
High

Gabapentin vs pregabalin

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Gabapentin changes risk for at least one adverse event per patient compared with pregabalin (very low certainty).

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
RR 4.7 [0.21, 104.14]
2 studies · 122 participants
Very low

Gabapentin vs pregabalin

Pruritus · patients with chronic kidney disease (CKD) pruritus

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 100 participants
Low

Gabapentin vs pregabalin

Quality of life ‐ not reported · patients with chronic kidney disease (CKD) pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pruritus in adult palliative care patients 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found