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Evidence found and GRADE certainty

4,315 questions · 23,557 findings · 2,311 reviews

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No studies found 4,183 · 17.8%GRADE not reported 3,930 · 16.7%Very low 5,371 · 22.8%Low 5,787 · 24.6%Moderate 3,320 · 14.1%High 966 · 4.1%

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Intervention not reported

TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid, aprotinin or…
1 finding from 1 review

Artemisia desertorum spreng (Shahaosan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Dental caries prevalence · Children (<18 years) with intellectual and developmental disabilities (IDD) in India

Dental caries affects about 64% of children with IDD in India (pooled prevalence 0.64, 95% CI 0.45-0.79; high heterogeneity; ungraded).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Periodontal disease prevalence · Children (<18 years) with intellectual and developmental disabilities (IDD) in India

In the single study reporting it, periodontal disease prevalence was 54.2% (single study; ungraded).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Early childhood caries (ECC) · Children younger than 71 months (under 6 years)

Pooled ECC prevalence in Europe was 36% (95% CI 25-47).

16 findings from 1 review
Show 13 more findings

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Regular toothbrushing usage (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India

About 91% of children with IDD in India use a toothbrush regularly (pooled prevalence 0.91, 95% CI 0.80-0.96; high heterogeneity; ungraded).

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Poor (inadequate) oral hygiene (prevalence) · Children (<18 years) with intellectual and developmental disabilities (IDD) in India

Poor oral hygiene affects about 38% of children with IDD in India (pooled prevalence 0.38, 95% CI 0.21-0.59; high heterogeneity; ungraded).

1 finding from 1 review

Chlorhexidine rinse (0.2%) pre- and post-extraction vs Chlorhexidine rinse (0.2%) post-extraction only

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.2%) pre- and post-extraction showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%) post-extraction only; GRADE not reported.

1 finding from 1 review

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8)

Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort)

The present Japanese GWAS found no genome-wide-significant loci for periodontal disease (top suggestive rs12624579/SYNDIG1); ungraded.

1 finding from 1 review
  • Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes
    Lifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)
    In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron).
    1 study · 45525 participants
    GRADE not reported

Genetically predicted gene expression (TWAS; S-PrediXcan with GTEx v8 cis-eQTL across 49 tissues; cross-tissue S-MultiXcan) vs ECC-unaffected children (association of genetically predicted expression)

Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.

1 finding from 1 review

Genetically predicted gene expression (TWAS; S-PrediXcan with GTEx v8 cis-eQTL across 49 tissues; cross-tissue S-MultiXcan) vs ECC-unaffected children (association of genetically predicted expression)

Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)

Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.

1 finding from 1 review

AI systems for caries detection/segmentation on dental X-ray images (predominantly convolutional neural networks; also ANNs, DNNs, DCNN, FCNN, SVMs, decision trees, random forests; e.g. EfficientNet, ResNet, AlexNet) vs Human dentists / trained dental professionals or traditional radiographic interpretation (reference standard / reference models)

Diagnostic accuracy (prevalence of accuracy) · Patients undergoing dental X-ray (radiographic) imaging for caries detection

On digital bitewing X-rays, AI accuracy was around 80% (single study, narrow CI; ungraded subgroup, numeric estimate not precisely readable).

4 findings from 1 review
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Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review