Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 15 reviews

No studies found 11 · 16.2%GRADE not reported 2 · 2.9%Very low 16 · 23.5%Low 14 · 20.6%Moderate 14 · 20.6%High 11 · 16.2%

Nasal prongs vs nasopharyngeal catheter

Treatment failure Failure to achieve adequate oxygenation (SaO2 greater than 60 mmHg) · children with acute lower respiratory tract infections

It is very uncertain whether nasal prongs changes treatment failure Failure to achieve adequate oxygenation (SaO2) compared with nasopharyngeal catheter (very low certainty).

1 finding from 1 review

Mask vs nasopharyngeal catheter

Treatment failure Failure to achieve adequate oxygenation (SaO2 greater than 60 mmHg) · children with severe acute LRTIs

Face mask may leads to lower treatment failure Failure to achieve adequate oxygenation (SaO2… compared with nasopharyngeal catheter (low certainty).

1 finding from 1 review

Head box vs nasopharyngeal catheter

Treatment failure Failure to achieve adequate oxygenation (SaO2 greater than 60 mmHg) · children with severe acute LRTIs

It is very uncertain whether head box changes treatment failure Failure to achieve adequate oxygenation (SaO2… compared with nasopharyngeal catheter (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU

It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU

It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Myocardial infarction · adults admitted to the ICU

It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Stroke · adults admitted to the ICU

It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher vs lower FiO2 or targets of arterial oxygenation

Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU

It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review