Self-reported tooth brushing · Adults (aged 18 or over) diagnosed with periodontal disease (gingivitis or periodontitis)
1 finding from 1 review
Oral cancer risk · People with and without more than 15 missing teeth
More than 15 missing teeth was associated with higher odds of oral cancer.
1 finding from 1 review
OR 1.91 [1.01, 3.62]
5 studies
GRADE not reported
Intervention not reported
Oral cancer (OC)
The intervention led to higher oral cancer (OC); GRADE not reported.
1 finding from 1 review
OR 2.63 [1.92, 3.62]
7 studies
GRADE not reported
Direct costs (medication, hospital bed days) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
The review found no eligible studies for this question.
1 finding from 1 review
Number of individuals with eating difficulties (8 days after administration); duration of eating difficulties · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir led to lower number of individuals with eating difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Difficulty in drinking (number with drinking difficulties) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir led to lower number of individuals with drinking difficulties (8 days after… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Number of individuals admitted to hospital after administration · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
Systemic oral acyclovir showed no clear difference in number of individuals admitted to hospital after administration compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Duration of fever · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Patient or parental satisfaction (tolerance and acceptability of drug) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Adverse effects · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
QoL · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
The review found no eligible studies for this question.
1 finding from 1 review
Mean time to resolution of pain · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
1 finding from 1 review
Amir 1997b: no data available. Ducoulombier 1988: time to resolution of pain, acyclovir (1 day=1, 2 days=1, 3 days=3, 4 days=3, 5 days=1, persistent=0) vs placebo (1 day=0, 2 days=0, 3 days=1, 4 days=2, 5 days=4,…
1 study · 18 participants
GRADE not reported
Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Gingivitis · Adults, 16 years and older (dentate)
It is very uncertain whether oral irrigation plus toothbrushing changes gingivitis (gingival index) compared with flossing plus toothbrushing (very low certainty).
2 findings from 1 review
Periodontitis (probing pocket depth) · Adults, 16 years and older (dentate)
1 finding from 1 review
Gingivitis · Adults, 16 years and older (dentate)
It is very uncertain whether oral irrigation plus toothbrushing changes gingivitis (gingival index) compared with toothbrushing alone (very low certainty).
2 findings from 1 review
Plaque · Adults, 16 years and older (dentate)
Oral irrigation plus toothbrushing showed no clear difference in plaque compared with toothbrushing alone (low certainty).
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
5 studies
GRADE not reported
Plaque · Adults, 16 years and older (dentate)
It is very uncertain whether oral irrigation plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).
1 finding from 1 review
Interproximal caries · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review