Findings

What do systematic reviews say?

158 questions · 175 findings · 31 reviews · Headline outcomes only

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No studies found 41 · 23.4%GRADE not reported 0 · 0%Very low 48 · 27.4%Low 63 · 36%Moderate 20 · 11.4%High 3 · 1.7%

Morphine vs buprenorphine

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs buprenorphine

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 113 participants
Moderate

Morphine vs buprenorphine

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Moderate

Morphine vs buprenorphine

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.5]
3 studies · 113 participants
Very low

Morphine vs dilute tincture of opium

Treatment failure · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs dilute tincture of opium

Seizures · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs dilute tincture of opium

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs dilute tincture of opium

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs dilute tincture of opium

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Morphine vs dilute tincture of opium

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Low

Morphine vs dilute tincture of opium

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs methadone

Treatment failure To discharge · newborn infants with opioid withdrawal

Morphine showed no clear difference in treatment failure To discharge compared with methadone (low certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 1.59 [0.95, 2.67]
2 studies · 147 participants
Low

Morphine vs methadone

Seizures · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs fentanyl

Pain (PIPP) · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs fentanyl

Duration of mechanical ventilation · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs fentanyl

Neonatal mortality · neonates with mechanical ventilation

The review found no eligible studies for this question.

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs fentanyl

Mortality before hospital discharge · neonates with mechanical ventilation

It is very uncertain whether morphine changes mortality to discharge compared with fentanyl (very low certainty).

1 finding from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
RR 1.21 [0.43, 3.45]
1 study · 163 participants
Very low

Morphine vs fentanyl

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Opioids for newborn infants receiving mechanical ventilation 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Morphine vs metamizole

Improvements in pain intensity as defined by the trialist (primary outcome) · participants with acute pancreatitis pain

Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).

1 finding from 1 review

Opioids for acute pancreatitis pain 2013 · Cochrane Headline outcomes only
RR 0.5 [0.19, 1.33]
1 study · 16 participants
Low

Consumption of intravenous morphine equivalents (mg): PCA vs non‐patient controlled opioid analgesia

Consumption of morphine equivalents 0 to 24 hmg · patients with postoperative pain

1 finding from 1 review

Patient controlled opioid analgesia versus non‐patient controlled opioid analgesia for postoperative pain 2015 · Cochrane Headline outcomes only
no estimate extracted
25 studies · 1586 participants
Low