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Evidence found and GRADE certainty

168 questions · 185 findings · 32 reviews

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No studies found 41 · 22.2%GRADE not reported 10 · 5.4%Very low 48 · 25.9%Low 63 · 34.1%Moderate 20 · 10.8%High 3 · 1.6%

Morphine vs buprenorphine

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

It is very uncertain whether morphine changes adverse events (treatment‐related) To discharge compared with buprenorphine (very low certainty).

1 finding from 1 review

Morphine vs fentanyl

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review

Morphine vs metamizole

Improvements in pain intensity as defined by the trialist (primary outcome) · participants with acute pancreatitis pain

Morphine showed no clear difference in improvements in pain intensity as defined by the trialist (primary… compared with metamizole (low certainty).

1 finding from 1 review

Morphine vs Tricyclic antidepressant (nortriptyline)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine led to lower average pain scores (0-100 VAS) compared with tricyclic antidepressant (nortriptyline); GRADE not reported.

1 finding from 1 review