Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

115 questions · 123 findings · 9 reviews · Dementia and Cognitive Improvement

No studies found 13 · 10.6%GRADE not reported 11 · 8.9%Very low 13 · 10.6%Low 25 · 20.3%Moderate 37 · 30.1%High 24 · 19.5%

Souvenaid vs placebo

Memory (specific cognitive function) · Apathy in people with mild‐to‐moderate Alzheimer's disease
1 finding from 1 review

Souvenaid vs placebo

Executive function (specific cognitive function) · Apathy in people with mild‐to‐moderate Alzheimer's disease
1 finding from 1 review

Souvenaid vs placebo

Combined cognitive‐functional outcome · Apathy in people with mild‐to‐moderate Alzheimer's disease
1 finding from 1 review

Souvenaid vs placebo

Any adverse events · Apathy in people with mild‐to‐moderate Alzheimer's disease

Souvenaid showed no clear difference in any adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Clinical Global (CIBIC+) · Alzheimer's disease (AD), moderate‐to‐severe
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 2797 participants
    High

Intervention not reported

Clinical Global: (CIBIC+) · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 757 participants
    Moderate

Intervention not reported

Cognitive function: ADAS‐Cog 70‐point scale · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 569 participants
    Moderate

Intervention not reported

Performance on ADL (NOSGER self care subscale) Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Behaviour: NOSGER disturbing behaviour subscale Subscale 5 points · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 542 participants
    Low

Intervention not reported

Binary outcomes · vascular dementia, mild‐to‐moderate severity

The review found no eligible studies for this question.

1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Intervention not reported

All‐cause discontinuation · vascular dementia, mild‐to‐moderate severity
1 finding from 1 review
  • Memantine for dementia 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 900 participants
    Low