Cochrane · systematic review · CD003154
Memantine for dementia
McShane, R, Westby, MJ, Roberts, E, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Dementia and Cognitive ImprovementAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
18
current version
GRADE rated
16
No studies
2
Included studies
NR
No studies 2 · 11.1%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 27.8%Moderate 3 · 16.7%High 8 · 44.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Moderate‐to‐severe AD, six to seven months
Population: Alzheimer's disease (AD), moderate‐to‐severe
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical Global (CIBIC+) | no estimate extracted | 10 studies · 2797 participants | High |
Cognitive Function (SIB) | no estimate extracted | 13 studies · 3337 participants | High |
Functional performance on activities of daily living: ADCS‐ADL19 54‐point scale | no estimate extracted | 11 studies · 2687 participants | High |
Behaviour and Mood (NPI) | no estimate extracted | 14 studies · 3674 participants | High |
Binary outcomes | no estimate extracted | NR | No studies |
All‐cause discontinuation | no estimate extracted | 17 studies · 5087 participants | High |
Number suffering at least one adverse event | no estimate extracted | 29 studies · 8033 participants | High |
Number suffering at least one serious adverse event | no estimate extracted | 19 studies · 6482 participants | High |
Number suffering agitation as an adverse event | no estimate extracted | 12 studies · 4395 participants | Moderate Downgraded: inconsistency |
Vascular dementia ‐ mild‐to‐moderate severity. six months
Population: vascular dementia, mild‐to‐moderate severity
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical Global: (CIBIC+) | no estimate extracted | 2 studies · 757 participants | Moderate Downgraded: imprecision, inconsistency |
Cognitive function: ADAS‐Cog 70‐point scale | no estimate extracted | 2 studies · 569 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Performance on ADL (NOSGER self care subscale) Subscale 5 points | no estimate extracted | 2 studies · 542 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Behaviour: NOSGER disturbing behaviour subscale Subscale 5 points | no estimate extracted | 2 studies · 542 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Binary outcomes | no estimate extracted | NR | No studies |
All‐cause discontinuation | no estimate extracted | 2 studies · 900 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Number suffering at least one adverse event | no estimate extracted | 29 studies · 8033 participants | High |
Number suffering at least one serious adverse event | no estimate extracted | 2 studies · 900 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Number suffering agitation as an adverse event | no estimate extracted | 2 studies · 900 participants | Low Downgraded: risk of bias, imprecision, inconsistency |