Miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin showed no clear difference in miscarriage rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
1 finding from 1 review
Gastrointestinal adverse events · women with polycystic ovary syndrome
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Ovulation rate · women with polycystic ovary syndrome
Metformin may leads to higher ovulation rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Live birth rate per woman · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Menstrual frequency per woman · women with polycystic ovary syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Gastrointestinal adverse events · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Miscarriage · women with polycystic ovary syndrome
It is very uncertain whether metformin changes miscarriage rate per woman compared with clomiphene citrate (very low certainty).
1 finding from 1 review
Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Menstrual frequency per woman · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin may leads to higher menstrual frequency per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Ovulation rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher ovulation rate per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Miscarriage · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Live birth rate per woman · subfertile women with polycystic ovary syndrome
Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Multiple pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Ongoing pregnancy · subfertile women with polycystic ovary syndrome
Metformin may leads to higher ongoing pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Clinical pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Improvement in acne severity · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Improvement in testosterone level (nmol/L) after 6 months' treatment · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Adverse effects · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
no estimate extracted
2011 participants
GRADE not reported
Resumption of menstrual regularity · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
Resumption of spontaneous ovulation · women with polycystic ovary syndrome not actively trying to conceive
1 finding from 1 review
no estimate extracted
2011 participants
GRADE not reported