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Evidence found and GRADE certainty

1,266 questions · 1,314 findings · 160 reviews · Headline outcomes only

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No studies found 309 · 23.5%GRADE not reported 34 · 2.6%Very low 356 · 27.1%Low 393 · 29.9%Moderate 187 · 14.2%High 35 · 2.7%

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Death or stroke · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment probably leads to higher death or stroke compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Long‐term ipsilateral stroke · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment probably leads to higher ipsilateral stroke compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Type of recurrent event · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment showed no clear difference in type of recurrent event compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Death · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment may leads to higher death compared with conventional medical treatment alone (low certainty).

1 finding from 1 review

Endovascular therapy plus conventional medical treatment vs conventional medical treatment alone

Dependency · people with symptomatic intracranial artery stenosis

Endovascular therapy plus conventional medical treatment showed no clear difference in dependency compared with conventional medical treatment alone (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Rehabilitation‐related activity interventions vs usual care with or without sham interventions

Medical deterioration during hospitalisation · acutely hospitalised older medical patients

It is very uncertain whether summary of findings table ‐ Rehabilitation‐related activity… changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Structured exercise interventions vs usual care with or without sham interventions

Medical deterioration during hospitalisation · acutely hospitalised older medical patients

It is very uncertain whether summary of findings table ‐ Structured exercise interventions changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Progressive resistance exercise interventions vs usual care with or without sham interventions

Medical deterioration during hospitalisation · acutely hospitalised older medical patients

It is very uncertain whether summary of findings table ‐ Progressive resistance exercise… changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

1 finding from 1 review

Exercise vs usual care with or without sham interventions

Medical deterioration during hospitalisation · acutely hospitalised medical patients

It is very uncertain whether summary of findings table ‐ Exercise interventions changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

1 finding from 1 review

ICD plus optimal medical therapy vs optimal medical therapy alone

All‐cause mortality (HR) ‐ main analysisa 16.5 to 67.6 months · DCM (non‐ischaemic)

ICD plus optimal medical therapy leads to lower all‐cause mortality (HR) ‐ main analysisa 16.5 to 67.6 months compared with optimal medical therapy alone (high certainty).

1 finding from 1 review

ICD plus optimal medical therapy vs optimal medical therapy alone

Noncardiovascular mortality (RR)b 22.8 to 67.6 months · DCM (non‐ischaemic)

ICD plus optimal medical therapy showed no clear difference in noncardiovascular mortality (RR)b 22.8 to 67.6 months compared with optimal medical therapy alone (moderate certainty).

1 finding from 1 review