Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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GnRH agonist plus chemotherapy vs chemotherapy alone

Adverse effects: vaginal dryness · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

GnRH agonist plus chemotherapy showed no clear difference in adverse effects: vaginal dryness compared with chemotherapy alone (moderate certainty).

1 finding from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · neoadjuvant therapy for early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review