Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

143 questions · 151 findings · 35 reviews · Headline outcomes only

No studies found 19 · 12.6%GRADE not reported 30 · 19.9%Very low 27 · 17.9%Low 39 · 25.8%Moderate 33 · 21.9%High 3 · 2%

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

Serious adverse events at up to 5‐year · 9‐ to 14‐year‐old females and males

It is very uncertain whether two doses of HPV vaccine with longer interval changes serious adverse events at up to 5‐year compared with two doses of HPV vaccine with shorter interval (very low certainty).

1 finding from 1 review

Intervention not reported

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer, occurring during the procedure · Procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review

Steroids vs cyclosporine A

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids showed no clear difference in change in TBUT (seconds) (longer is favored) compared with cyclosporine A (low certainty).

1 finding from 1 review

Steroids vs lubricants

Change in TBUT (seconds) (longer is favored) · people with dry eye

Steroids may leads to higher change in TBUT (seconds) (longer is favored) compared with lubricants (low certainty).

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Repeat midurethral tape (any type) vs any other non‐tape surgical treatment (e.g. traditional sling, colposuspension, injectables)

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

One type of repeat midurethral tape vs another type of repeat midurethral tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Alpha2‐adrenergic agonist vs control

Acute stroke (within 30‐days after surgery: new focal neurologic deficit with signs and symptoms lasting longer than 24 hours) · adults undergoing cardiac surgery

Alpha‐2 adrenergic agonists may leads to lower acute stroke (within 30‐days after surgery: new focal neurologic… compared with control (low certainty).

1 finding from 1 review