Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 205 findings · 42 reviews

No studies found 23 · 11.2%GRADE not reported 64 · 31.2%Very low 31 · 15.1%Low 51 · 24.9%Moderate 33 · 16.1%High 3 · 1.5%

Longer intervals (5‐15 days) (intervention) vs shorter intervals (2‐5 days) (control) between dressing changes

Pain № of participants: 193 (2 RCTs) · patients with a central venous catheter

Longer intervals (5‐15 days) (intervention) showed no clear difference in pain № of participants: 193 (2 RCTs) compared with shorter intervals (2‐5 days) (control) between dressing changes (low certainty).

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

High‐grade cervical, vulval, vaginal, penile, or anal intraepithelial neoplasia · 9‐ to 14‐year‐old females and males

The review found no eligible studies for this question.

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

Serious adverse events at up to 5‐year · 9‐ to 14‐year‐old females and males

It is very uncertain whether two doses of HPV vaccine with longer interval changes serious adverse events at up to 5‐year compared with two doses of HPV vaccine with shorter interval (very low certainty).

1 finding from 1 review

Partial pulpotomy with one-unit longer follow-up vs Partial pulpotomy with one-unit shorter follow-up

Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure

In the high-risk-study-excluded sensitivity meta-regression, longer follow-up was associated with lower success.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Severe pain for > 1 week · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher severe pain for > 1 week compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Experienced the operation negatively · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in experienced the operation negatively compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

No improvement of facial appearance (3 weeks) · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to lower no improvement of facial appearance (3 weeks) compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Prosthetic failure (2 years) · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in prosthetic failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Major complications · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… led to higher major complications compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer implants (vertical augmentation) vs Short implants (8 to 11 mm) without augmentation

Implant failure · Patients with atrophic (resorbed) mandibles needing implants

Inlay/interposed bone graft (iliac or Bio-Oss block) + longer… showed no clear difference in implant failure compared with short implants (8 to 11 mm) without augmentation; GRADE not reported.

1 finding from 1 review

Intervention not reported

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer, occurring during the procedure · Procedural pain in neonates

The review found no eligible studies for this question.

1 finding from 1 review