Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

55 questions · 57 findings · 15 reviews · Neonatal

No studies found 17 · 29.8%GRADE not reported 0 · 0%Very low 12 · 21.1%Low 21 · 36.8%Moderate 7 · 12.3%High 0 · 0%

LCPUFA supplemented formula vs control formula

Head circumference at 12 months (z scores) ‐ DHA and AA vs normal term formula · term infants

LCPUFA supplemented formula showed no clear difference in head circumference at 12 months (z scores) ‐ DHA and AA vs normal… compared with control formula (low certainty).

1 finding from 1 review

Intervention not reported

Bayley MDI at 12 months post‐term · Preterm infants on enteral feed

The intervention showed no clear difference in bayley MDI at 12 months post‐term (low certainty).

1 finding from 1 review

Intervention not reported

Bayley PDI at 12 months post‐term · Preterm infants on enteral feed

The intervention showed no clear difference in bayley PDI at 12 months post‐term (low certainty).

1 finding from 1 review

Intervention not reported

Weight at 12 months post‐term (kg) · Preterm infants on enteral feed

The intervention showed no clear difference in weight at 12 months post‐term (kg) (low certainty).

1 finding from 1 review

Intervention not reported

Length at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in length at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Intervention not reported

Head circumference at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in head circumference at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Vitamin A vs no supplementation

Chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in chronic lung disease (oxygen use at 28 days in survivors) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A vs no supplementation

Death or chronic lung disease · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A probably leads to lower death or chronic lung disease (oxygen use at 28 days) compared with no supplementation (moderate certainty).

2 findings from 1 review

Vitamin A vs no supplementation

Death before 36 weeks' postmenstrual age · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in death before 36 weeks' postmenstrual age compared with no supplementation (moderate certainty).

1 finding from 1 review

Vitamin A vs no supplementation

Neurodevelopmental impairment at 18 to 22 months · promoting growth and development in very low birth weight infants receiving human milk

Supplemental vitamin A showed no clear difference in neurodevelopmental impairment at 18 to 22 months compared with no supplementation (low certainty).

1 finding from 1 review