Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 122 findings · 18 reviews · Common Mental Disorders

No studies found 29 · 23.8%GRADE not reported 12 · 9.8%Very low 39 · 32%Low 28 · 23%Moderate 14 · 11.5%High 0 · 0%

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) long term (longer than 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) long term (longer than 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

MAOIs vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with SAnD

It is very uncertain whether comparison 7: MAOIs changes clinical Global Impressions scale change item (CGI‐I):no. of… compared with placebo (very low certainty).

1 finding from 1 review

Comparison 10: RIMAs vs placebo

Clinical Global Impressions ‐ Improvement of condition (CGI‐I) Rating of 1 = very much improved to 7 = very much worse · adults with SAnD

Comparison 10: RIMAs probably leads to higher clinical Global Impressions scale change item (CGI‐I): no. of… compared with placebo (moderate certainty).

1 finding from 1 review

Comparison 13: SSRIs vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with SAnD

Comparison 13: SSRIs may leads to higher clinical Global Impressions scale change item (CGI‐I): no. of… compared with placebo (low certainty).

1 finding from 1 review

Comparison 13: SSRIs vs placebo

Dropouts due to adverse events · adults with SAnD

It is very uncertain whether comparison 13: SSRIs changes dropouts due to adverse events (long term) Post‐treatment: 1‐4 months compared with placebo (very low certainty).

1 finding from 1 review