Findings

What do systematic reviews say?

45 questions · 45 findings · 6 reviews

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No studies found 8 · 17.8%GRADE not reported 1 · 2.2%Very low 15 · 33.3%Low 2 · 4.4%Moderate 8 · 17.8%High 11 · 24.4%

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
4 days (not usable)
One study (Lauritano 2000) compared ketoprofen 160 mg with benzidamine chloride 22.5 mg mouthwashes; it presented data at 4 days only, so the data could not be used in this review; no GRADE rating.
1 study
GRADE not reported

Topical NSAID (ketoprofen lysinate mouthwash, 160 mg) vs Topical NSAID (benzidamine hydrochloride mouthwash, 22.5 mg)

Adverse events · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
The study did not report this outcome.
0 studies
No studies found

Intervention not reported

Topical ketoprofen gel Clinical success (for example 50% reduction in pain) · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 2573 participants
Moderate

Intervention not reported

Topical ketoprofen gel Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 2621 participants
Moderate

Topical NSAIDs vs topical placebo

At least 50% reduction in pain · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 348 participants
Moderate