Findings

What do systematic reviews say?

63 questions · 63 findings · 9 reviews · Neonatal

Sort:Best matchNewest Highest certainty Download CSV

No studies found 10 · 15.9%GRADE not reported 2 · 3.2%Very low 13 · 20.6%Low 22 · 34.9%Moderate 16 · 25.4%High 0 · 0%

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.32 [0.56, 3.14]
1 study · 67 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Mortality (all infants): 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in mortality (all infants): 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.82 [0.84, 9.46]
1 study · 64 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Bleeding complications: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in bleeding complications: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.81 [0.2, 3.27]
1 study · 54 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2 [0.19, 20.72]
1 study · 52 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 0.72 [0.13, 3.96]
1 study · 54 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 5: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.52 [0.37, 6.23]
1 study · 60 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 5: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 2.07 [0.41, 10.43]
1 study · 57 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25: 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25: 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.08 [0.07, 16.36]
1 study · 52 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1.04 [0.07, 15.74]
1 study · 51 participants
Low

Intramuscular vitamin K vs intravenous vitamin K

Necrotizing enterocolitis ‐ 0.2 mg IV versus 0.2 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in necrotizing enterocolitis ‐ 0.2 mg IV versus 0.2 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates 2018 · Cochrane Headline outcomes only
RR 1 [0.15, 6.57]
1 study · 52 participants
Low

Intervention not reported

Mortality during hospital stay · neonates requiring intubation and ventilation

The intervention showed no clear difference in mortality during hospital stay (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 0.79 [0.4, 1.56]
3 studies · 122 participants
Moderate

Intervention not reported

Length of NICU stay (days) · neonates requiring intubation and ventilation

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
5.4 [0.4, 10.5]
2 studies · 89 participants
Moderate

Intervention not reported

PIPP score during drug infusion Range of scale 0‐21 for infants < 28 weeks' PMA and 0‐18 for infants > 36 weeks' PMA. Lower score = less pain (Stevens 1996) · neonates requiring intubation and ventilation

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Moderate

Intervention not reported

Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation

The intervention showed no clear difference in poor neurological outcome by 28 days' postnatal age (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 1.34 [0.5, 3.56]
1 study · 43 participants
Moderate

Intervention not reported

The intervention showed no clear difference in PIPP score during drug infusion Range of scale 0‐21 for infants < 28… (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
MD 1
1 study · 46 participants
Moderate

Intervention not reported

Poor neurological outcome by 28 days' postnatal age · neonates requiring intubation and ventilation

The intervention probably leads to higher poor neurological outcome by 28 days' postnatal age (moderate certainty).

1 finding from 1 review

Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit 2017 · Cochrane Headline outcomes only
RR 7.64 [1.02, 57.21]
1 study · 46 participants
Moderate

Intervention not reported

Mortality during hospitalisation number of infants with event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in mortality during hospitalisation number of infants with event (moderate certainty).

1 finding from 1 review

Intravenous in‐line filters for preventing morbidity and mortality in neonates 2015 · Cochrane Headline outcomes only
RR 0.87 [0.52, 1.47]
2 studies · 530 participants
Moderate

Intervention not reported

Risk of proven septicaemia per infant number of infants with the event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in risk of proven septicaemia per infant number of infants with the event (moderate certainty).

1 finding from 1 review

Intravenous in‐line filters for preventing morbidity and mortality in neonates 2015 · Cochrane Headline outcomes only
RR 0.86 [0.59, 1.27]
2 studies · 530 participants
Moderate

Intervention not reported

Suspected septicaemia number of infants with the event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in suspected septicaemia number of infants with the event (low certainty).

1 finding from 1 review

Intravenous in‐line filters for preventing morbidity and mortality in neonates 2015 · Cochrane Headline outcomes only
RR 0.57 [0.18, 1.81]
1 study · 88 participants
Low

Intervention not reported

Localised thrombi number of infants with event · patients with preventing morbidity and mortality in neonates

The intervention showed no clear difference in localised thrombi number of infants with event (low certainty).

1 finding from 1 review

Intravenous in‐line filters for preventing morbidity and mortality in neonates 2015 · Cochrane Headline outcomes only
RR 0.2 [0.01, 4.05]
1 study · 88 participants
Low