HIV Transmission at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 24 months among those uninfected at birth11 compared with sdNVP plus ZDV (1week) (moderate certainty).
1 finding from 1 review
Intervention not reported
Infant with Toxicity Events leading to cessation of ZDV · breastfeeding infants of HIV‐infected mothers
It is very uncertain whether the intervention changes infant with Toxicity Events leading to cessation of ZDV (very low certainty).
1 finding from 1 review
HIV transmission at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose HIV diagnostic… compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes HIV Transmission or Death at 6 months among those whose HIV… compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).
1 finding from 1 review
Infant Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infants with Grade 3/4 Severe Adverse Events compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Maternal mortality ‐ not reported · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in maternal Mortality at 6 months compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in mothers with any Grade 3/4 Severe Adverse Event compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Mothers with Severe Adverse Events Requiring Treatment Modification · HIV‐infected mothers and their breastfeeding infants
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes mothers with Severe Adverse Events Requiring Treatment Modification compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).
1 finding from 1 review
HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
1 finding from 1 review
HIV transmission at 12 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers may leads to lower HIV transmission at 12 months among those whose diagnostic testing… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
1 finding from 1 review
Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 14 weeks showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1week) (moderate certainty).
1 finding from 1 review
Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
1 finding from 1 review
Infant Mortality at 12 months · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 12 months compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
1 finding from 1 review
HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission or Death at 6 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (low certainty).
1 finding from 1 review
HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers probably leads to lower HIV transmission or Death at 12 months among those whose HIV… compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (moderate certainty).
1 finding from 1 review
Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes maternal Grade 3/4 Severe Adverse Events compared with short course ZDV (intrapartum ZDV/3TC/sdNVP) (very low certainty).
1 finding from 1 review
HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants
An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (moderate certainty).
1 finding from 1 review
Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants
An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in infant mortality at 28 weeks among those whose diagnostic testing… compared with 1 week of antiretroviral prophylaxis (low certainty).
1 finding from 1 review
HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants
An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).
1 finding from 1 review