Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

418 questions · 423 findings · 44 reviews · Eyes and Vision

No studies found 122 · 28.8%GRADE not reported 26 · 6.1%Very low 98 · 23.2%Low 120 · 28.4%Moderate 53 · 12.5%High 4 · 0.9%

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Change in visual loss associated with PSR: visual loss is defined by the deterioration of visual acuity of 3 lines or more with the Snellen chart · type 1 or type 2 diabetics

It is very uncertain whether blood pressure intervention/intensive blood pressure intervention changes visual acuity (loss of 3 lines or more) by 5 years compared with placebo/standard blood pressure intervention (very low certainty).

1 finding from 1 review

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Adverse events: hypotension · type 1 or type 2 diabetics

Blood pressure intervention/intensive blood pressure intervention may leads to higher adverse events—hypotension compared with placebo/standard blood pressure intervention (low certainty).

1 finding from 1 review

Patching vs active observation

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged less than 11 years

The review found no eligible studies for this question.

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review

Intervention not reported

Comparison (intervention vs comparator) · children with myopia (nearsightedness)

The review found no eligible studies for this question.

1 finding from 1 review

Steroid implant vs sham

Proportion of participants with elevated IOP or receiving intervention · people with chronic non‐infectious uveitis

Steroid implant probably leads to higher proportion of participants with elevated IOP or receiving intervention compared with sham procedure (moderate certainty).

1 finding from 1 review

Telerehabilitation vs self‐training

Technical difficulties · people with any eye disease including optic nerve disease, age‐related macular degeneration, retinopathy of prematurity, retinitis…

It is very uncertain whether telerehabilitation changes technical difficulties with the intervention at 6 months compared with self‐training (very low certainty).

1 finding from 1 review