Findings

What do systematic reviews say?

46 questions · 52 findings · 4 reviews · Airways

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No studies found 5 · 9.6%GRADE not reported 0 · 0%Very low 1 · 1.9%Low 13 · 25%Moderate 25 · 48.1%High 8 · 15.4%

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review

Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
RR 0.92 [0.82, 1.02]
Studies not reported
High
Intermittent prophylactic antibiotics for bronchiectasis 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Maintenance LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 1.2 [0.7, 2.06]
1 study · 347 participants
Moderate

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring ED visit · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.66 [0.37, 1.2]
1 study · 347 participants
Moderate

Maintenance LTRA vs placebo

Number of participants experiencing one or more episodes requiring hospital admission · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episodes requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.65 [0.23, 1.87]
1 study · 347 participants
Moderate

Maintenance LTRA vs placebo

Total number of withdrawals · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in withdrawals ‐ Total number of withdrawals compared with placebo (moderate certainty).

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
OR 0.87 [0.66, 1.13]
2 studies · 1729 participants
Moderate

Maintenance LTRA vs placebo

Serious adverse events · episodic viral wheeze in children

The review found no eligible studies for this question.

1 finding from 1 review

Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found