Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

72 questions · 72 findings · 12 reviews

No studies found 13 · 18.1%GRADE not reported 0 · 0%Very low 7 · 9.7%Low 21 · 29.2%Moderate 25 · 34.7%High 6 · 8.3%

Live attenuated influenza vaccine vs placebo or no intervention

Otitis media · healthy, community‐dwelling children younger than 16 years of age

Live attenuated influenza vaccine showed no clear difference in otitis media assessed by clinical confirmation (inspection of ear… compared with placebo or do nothing (moderate certainty).

1 finding from 1 review

Live attenuated influenza vaccine vs placebo or no intervention

Number of children with time off from school during · healthy, community‐dwelling children younger than 16 years of age

It is very uncertain whether live attenuated influenza vaccine changes number of children with time off from school during compared with placebo or do nothing (very low certainty).

1 finding from 1 review

Live attenuated influenza vaccine vs placebo or no intervention

Number of parents having to take off work during · healthy, community‐dwelling children younger than 16 years of age

Live attenuated influenza vaccine showed no clear difference in number of parents having to take off work during compared with placebo or do nothing (low certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Infant death (up to 175 days) · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in infant death (up to 175 days) compared with control (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Perinatal death (stillbirth + death in first week of life) · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in perinatal death (stillbirth + death in first week of life) compared with control (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Any respiratory illness in women · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in any respiratory illness in women compared with control (high certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Any respiratory illness in infants · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in any respiratory illness in infants compared with control (high certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Maternal hospitalisation for any infection · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in maternal hospitalisation for any infection compared with control (moderate certainty).

1 finding from 1 review

Viral influenza vaccine vs control

Neonatal hospitalisation due to sepsis within 28 days of birth · Pregnant women aged 18 to 38 years and an estimated gestation of 20 to 36 weeks.

Viral influenza vaccine showed no clear difference in neonatal hospitalisation due to sepsis within 28 days of birth compared with control (moderate certainty).

1 finding from 1 review

Enhancing vaccination access vs no intervention or another intervention

Free influenza vaccine compared to invitation to be vaccinated but patient pays · people aged 60 years and older living in the community

Enhancing vaccination access leads to higher free influenza vaccine compared to invitation to be vaccinated but… compared with no intervention or another intervention (high certainty).

1 finding from 1 review