Cochrane · systematic review · CD004879
Vaccines for preventing influenza in healthy children
Jefferson, T, Rivetti, A, Di Pietrantonj, C, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
10
No studies
6
Included studies
NR
No studies 6 · 37.5%Ungraded 0 · 0%Very low 3 · 18.8%Low 2 · 12.5%Moderate 4 · 25%High 1 · 6.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Live attenuated influenza vaccine compared to placebo or do nothing for preventing influenza in children
Population: healthy, community‐dwelling children younger than 16 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Influenza assessed by laboratory confirmation Live attenuated influenza vaccine vs placebo or do nothing | RR 0.22 [0.11, 0.41] | 7 studies · 7718 participants | Moderate Downgraded: risk of bias, inconsistency |
Influenza‐like illness assessed by subjective report Live attenuated influenza vaccine vs placebo or do nothing | RR 0.69 [0.6, 0.8] | 7 studies · 124606 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Otitis media assessed by clinical confirmation (inspection of ear and symptoms) Live attenuated influenza vaccine vs placebo or do nothing | RR 0.98 [0.95, 1.01] | 1 study · 1784 participants | Moderate Downgraded: imprecision, indirectness |
Number of children with time off from school during Live attenuated influenza vaccine vs placebo or do nothing | RR 0.51 [0.22, 1.19] | 1 study · 296 participants | Very low Downgraded: risk of bias, imprecision |
Number of parents having to take off work during Live attenuated influenza vaccine vs placebo or do nothing | RR 0.69 [0.46, 1.03] | 2 studies · 2874 participants | Low Downgraded: risk of bias |
Hospitalisation ‐ not reported Live attenuated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |
Fever assessed as reported increase in temperature Live attenuated influenza vaccine vs placebo or do nothing | no estimate extracted | 4 studies · 20561 participants | Very low Downgraded: risk of bias, inconsistency |
Nausea ‐ not reported Live attenuated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |
Inactivated influenza vaccine compared to placebo or do nothing for preventing influenza in children
Population: healthy, community‐dwelling children older than 2 years of age
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Influenza assessed by laboratory confirmation Inactivated influenza vaccine vs placebo or do nothing | RR 0.36 [0.28, 0.48] | 5 studies · 1628 participants | High |
Influenza‐like illness assessed by subjective report Inactivated influenza vaccine vs placebo or do nothing | RR 0.72 [0.65, 0.79] | 4 studies · 19044 participants | Moderate Downgraded: risk of bias |
Otitis media assessed by clinical confirmation (inspection of ear and symptoms) Inactivated influenza vaccine vs placebo or do nothing | RR 1.15 [0.95, 1.4] | 3 studies · 884 participants | Moderate Downgraded: imprecision |
Absence from school Inactivated influenza vaccine vs placebo or do nothing | RR 0.46 [0.17, 1.22] | 1 study · 254 participants | Very low Downgraded: risk of bias, imprecision |
Number of parents having to take off work during Inactivated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |
Hospitalisations ‐ not reported Inactivated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |
Fever ‐ not reported Inactivated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |
Nausea ‐ not reported Inactivated influenza vaccine vs placebo or do nothing | no estimate extracted | NR | No studies |