Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

56 questions · 57 findings · 5 reviews · Schizophrenia

No studies found 6 · 10.5%GRADE not reported 13 · 22.8%Very low 22 · 38.6%Low 13 · 22.8%Moderate 3 · 5.3%High 0 · 0%

Antipsychotic dose increase vs switching the antipsychotic drug

Clinically significant response on global state · non response in schizophrenia

It is very uncertain whether increasing the antipsychotic dose changes global state: Clinically relevant response – as defined by trial… compared with switching the antipsychotic drug (very low certainty).

1 finding from 1 review

Intervention not reported

Weight: Gain‐more than or equal to 7% from baseline · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

The intervention showed no clear difference in weight: Gain‐more than or equal to 7% from baseline (moderate certainty).

1 finding from 1 review