Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 60 findings · 9 reviews · Eyes and Vision

No studies found 12 · 20%GRADE not reported 2 · 3.3%Very low 10 · 16.7%Low 17 · 28.3%Moderate 16 · 26.7%High 3 · 5%

Combined steroid and antibiotic therapy vs antibiotics alone

Adverse events at 3 to 12 months' · eyes with acute endophthalmitis following an intraocular procedure (e.g. surgery, intravitreous injection)

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

1 finding from 1 review

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Improvement in visual acuity at 3 months' · people with endophthalmitis following intraocular surgery

It is very uncertain whether vitrectomy changes proportion of people with a visual acuity improvement of 10 letters… compared with vitreous tap biopsy and antibiotic injection (very low certainty).

1 finding from 1 review

Vitrectomy vs vitreous tap biopsy and antibiotic injection

Additional surgical procedure, including vitrectomy and cataract surgery. · people with endophthalmitis following intraocular surgery

Vitrectomy showed no clear difference in additional surgical procedure, including vitrectomy and cataract… compared with vitreous tap biopsy and antibiotic injection (low certainty).

1 finding from 1 review

Extended‐fixed vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in endophthalmitis (ocular adverse event) compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

As needed may leads to lower gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (low certainty).

1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Central retinal thickness μm (CRT) change at 1 year The aim of treatment is to reduce central retinal thickness so thinner is better. · people with neovascular age‐related macular degeneration
1 finding from 1 review

'As needed' administration (e.g. based on pain scales) vs monthly injections

Proportion of participants with endophthalmitis · people with neovascular age‐related macular degeneration

As needed probably leads to lower endophthalmitis (ocular adverse event) compared with monthly injections (moderate certainty).

1 finding from 1 review

Extended‐fixed vs monthly injections

Gain of 3 or more lines of visual acuity · people with neovascular age‐related macular degeneration

Extended‐fixed showed no clear difference in gain of ≥ 15 letters visual acuity at 1 year compared with monthly injections (moderate certainty).

1 finding from 1 review