Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

65 questions · 73 findings · 16 reviews

No studies found 8 · 11%GRADE not reported 19 · 26%Very low 10 · 13.7%Low 11 · 15.1%Moderate 14 · 19.2%High 11 · 15.1%

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
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Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.

5 findings from 1 review
Show 2 more findings

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review

Intervention not reported

Adverse effects during treatment Intervention: Hyperbaric chamber/ 160 millibars versus supplementary oxygen · people suffering from high altitude illness
1 finding from 1 review

Intervention not reported

Diabetic ulcers healed at 1 year. · patients with chronic wounds

The intervention showed no clear difference in diabetic ulcers healed at 1 year. (moderate certainty).

1 finding from 1 review

Intervention not reported

Diabetic ulcers ‐ major amputations · patients with chronic wounds

The intervention showed no clear difference in diabetic ulcers ‐ major amputations (moderate certainty).

1 finding from 1 review

Intervention not reported

Death at any time · patients with acute coronary syndrome

The intervention may leads to lower death at any time (low certainty).

1 finding from 1 review

Intervention not reported

hour Plasma Creatine Phosphokinase · patients with acute coronary syndrome
1 finding from 1 review

Intervention not reported

hour Plasma Creatine Phosphate · patients with acute coronary syndrome
1 finding from 1 review

Intervention not reported

Maximum Plasma Creatine Phosphate · patients with acute coronary syndrome
1 finding from 1 review

Intervention not reported

Death · people with acute ischaemic stroke

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review