What do systematic reviews say?

Summary of findings table ‐ Progestogens vs GnRH agonist

• Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 260 participants
  High

Summary of findings table ‐ Progestogens vs Progestogen 2

• Progestogens for prevention of luteinising hormone (LH) surge in women undergoing controlled ovarian hyperstimulation… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 0.82 [0.45, 1.49]
  1 study · 253 participants
  Low

LOD vs medical interventions

• Ovarian surgery for symptom relief in women with polycystic ovary syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in live birth rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.19 [0.87, 1.61]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in clinical pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 1.17 [0.85, 1.59]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

IVF showed no clear difference in multiple pregnancy rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 0.82 [0.38, 1.77]
  3 studies · 731 participants
  Low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

It is very uncertain whether IVF changes OHSS rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 6.86 [0.35, 134.59]
  1 study · 207 participants
  Very low

IVF vs IUI + ovarian stimulation with gonadotropins or CC

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with IUI + ovarian stimulation with gonadotropins or CC (very low certainty).

• In vitro fertilisation for unexplained subfertility 2023 · Cochrane Headline outcomes only
  OR 0.31 [0.03, 3.04]
  1 study · 207 participants
  Very low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in multiple pregnancy rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 3.03 [0.12, 75.06]
  1 study · 230 participants
  Low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

It is very uncertain whether gonadotrophins with anti‐oestrogens changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 1.99 [0.81, 4.9]
  2 studies · 328 participants
  Very low

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Gonadotrophins with anti‐oestrogens showed no clear difference in OHSS rate per couple compared with gonadotropins alone (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.5 [0.04, 5.54]
  1 study · 230 participants
  Low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors may leads to lower live birth rate per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.49 [0.34, 0.71]
  2 studies · 651 participants
  Low

Aromatase inhibitors vs gonadotropins alone

It is very uncertain whether aromatase inhibitors changes multiple pregnancy rate per couple compared with gonadotropins (very low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.69 [0.06, 8.17]
  3 studies · 731 participants
  Very low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors may leads to lower clinical pregnancy rate per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.61 [0.46, 0.82]
  6 studies · 1085 participants
  Low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors may leads to lower miscarriage rate per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.53 [0.3, 0.92]
  2 studies · 650 participants
  Low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors showed no clear difference in OHSS rate per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 1 [0.14, 7.2]
  2 studies · 680 participants
  Low

Aromatase inhibitors vs gonadotropins alone

Aromatase inhibitors showed no clear difference in ectopic pregnancy per couple compared with gonadotropins (low certainty).

• Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
  OR 0.56 [0.21, 1.48]
  2 studies · 650 participants
  Low