Myocardial infarction · preventing early recurrence after ischaemic stroke or TIA
Multiple showed no clear difference in myocardial infarction compared with fewer antiplatelet agents (high certainty).
1 finding from 1 review
Stroke, myocardial infarction, or vascular death · preventing early recurrence after ischaemic stroke or TIA
Multiple probably leads to lower stroke, myocardial infarction, or vascular death compared with fewer antiplatelet agents (moderate certainty).
1 finding from 1 review
Intracranial haemorrhage · preventing early recurrence after ischaemic stroke or TIA
Multiple may leads to higher intracranial haemorrhage compared with fewer antiplatelet agents (low certainty).
1 finding from 1 review
Extracranial haemorrhage · preventing early recurrence after ischaemic stroke or TIA
Multiple leads to higher extracranial haemorrhage compared with fewer antiplatelet agents (high certainty).
1 finding from 1 review
Ischaemic stroke · preventing early recurrence after ischaemic stroke or TIA
Multiple leads to lower ischaemic stroke compared with fewer antiplatelet agents (high certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Adults aged 18 years or older with mature permanent teeth and carious pulp exposure
Each additional day before permanent restoration was associated with a 0.088% decrease in success in meta-regression.
1 finding from 1 review
Early childhood caries experience (mean dmft) · Nigerian children with primary dentition (approximately 6 months to 5 years)
In primary dentition, high-frequency sugar consumption was associated with slightly higher, non-significant odds of caries (OR 1.13, 95% CI 0.23 to 5.44), with high heterogeneity (I2=83%; ungraded).
1 finding from 1 review
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
The number of missing teeth (per tooth) was not significantly associated with oral cancer (OR 0.96, 95% CI 0.92-1.01); ungraded.
1 finding from 1 review
Oral cancer risk · People with and without more than 15 missing teeth
More than 15 missing teeth was associated with higher odds of oral cancer.
1 finding from 1 review
OR 1.91 [1.01, 3.62]
5 studies
GRADE not reported
Malignant transformation (oral cancer development) · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling across all missing-teeth measures, the overall association with oral cancer was not statistically significant (OR 1.20, 95% CI 0.97-1.48; high heterogeneity, I2=82.8%); ungraded.
1 finding from 1 review
Dental caries in permanent teeth · Nigerian individuals with permanent dentition (approximately 12 years and older)
In permanent dentition, high-frequency sugar consumption was associated with non-significant 15% higher odds of caries (OR 1.15, 95% CI 0.88 to 1.52), with no heterogeneity (I2=0%; ungraded).
1 finding from 1 review
Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition
High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).
1 finding from 1 review
Intervention not reported
Total studies: 93 Total participants: 22,558 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
The intervention led to lower total studies: 93 Total participants: 22,558; GRADE not reported.
1 finding from 1 review
no estimate extracted
93 participants
GRADE not reported
Intervention not reported
Desvenlafaxine high dose RCTs: 2 Participants: 905 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
2 participants
Very low
Intervention not reported
Mirtazapine standard dose RCTs: 2 Participants: 457 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
2 participants
Very low
Intervention not reported
Duloxetine standard dose RCTs: 20 Participants: 4998 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
20 participants
Very low
Intervention not reported
Milnacipran standard dose RCTs: 8 Participants: 2491 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
8 participants
Very low
Intervention not reported
Duloxetine high dose RCTs: 10 Participants: 4000 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
10 participants
Very low
Intervention not reported
Duloxetine low dose RCTs: 6 Participants: 1031 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
6 participants
Very low
Intervention not reported
Milnacipran high dose RCTs: 7 Participants: 2837 · people with chronic pain Interventions: amitriptyline standard dose (25‐75 mg); desvenlafaxine high dose (> 50 mg); duloxetine low dose (<…
1 finding from 1 review
no estimate extracted
7 participants
Very low