Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

173 questions · 174 findings · 12 reviews · Headline outcomes only

No studies found 34 · 19.5%GRADE not reported 26 · 14.9%Very low 34 · 19.5%Low 40 · 23%Moderate 25 · 14.4%High 15 · 8.6%

Doxycycline 40 mg vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs other antibiotics

Adverse events considered non‐serious (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

All‐cause mortality (penicillin versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality (penicillin versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

All‐cause mortality (a cephalosporin (cefotaxime) versus doxycycline) · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality (a cephalosporin (cefotaxime) versus doxycycline) compared with other antibiotics (very low certainty).

1 finding from 1 review