Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 177 findings · 31 reviews

No studies found 18 · 10.2%GRADE not reported 33 · 18.6%Very low 50 · 28.2%Low 57 · 32.2%Moderate 19 · 10.7%High 0 · 0%

Fecal microbiota transplantation vs control

Resolution of rCDI · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) probably leads to higher resolution of rCDI compared with control (moderate certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

Serious adverse events · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in serious adverse events compared with control (moderate certainty).

1 finding from 1 review

Fecal microbiota transplantation vs control

All‐cause mortality · adults with recurrent Clostridioides difficile infection (rCDI)

Summary of findings table ‐ Fecal microbiota transplantation (FMT) showed no clear difference in all‐cause mortality compared with control (low certainty).

1 finding from 1 review

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

All‐cause long‐term mortality · people with unexplained recurrent syncope

It is very uncertain whether summary of findings for the main comparison. Implantable loop recorder changes all‐cause long‐term mortality compared with conventional diagnostic workup (very low certainty).

1 finding from 1 review

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

Aetiologic diagnosis · people with unexplained recurrent syncope

Summary of findings for the main comparison. Implantable loop recorder probably leads to lower aetiologic diagnosis compared with conventional diagnostic workup (moderate certainty).

1 finding from 1 review

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3 weeks for 27 weeks) vs placebo injection

Mean number of oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3… showed no clear difference in mean number of oral ulcers compared with placebo (saline IM injection); GRADE not reported.

1 finding from 1 review

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Episode duration associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Pain associated with oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
    Studies not reported
    GRADE not reported