Cochrane · systematic review · CD013871
Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile)
Minkoff, NZ, Aslam, S, Medina, M, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 25%Very low 0 · 0%Low 1 · 25%Moderate 2 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings table ‐ Fecal microbiota transplantation (FMT) compared to control in adults with recurrent Clostridioides difficile infection (rCDI)
Population: adults with recurrent Clostridioides difficile infection (rCDI)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Resolution of rCDI Summary of findings table ‐ Fecal microbiota transplantation (FMT) vs control | RR 1.92 [1.36, 2.71] | 6 studies · 320 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Serious adverse events Summary of findings table ‐ Fecal microbiota transplantation (FMT) vs control | RR 0.73 [0.38, 1.41] | 6 studies · 320 participants | Moderate Downgraded: imprecision |
All‐cause mortality Summary of findings table ‐ Fecal microbiota transplantation (FMT) vs control | RR 0.57 [0.22, 1.45] | 6 studies · 320 participants | Low Downgraded: imprecision |
Colectomy Summary of findings table ‐ Fecal microbiota transplantation (FMT) vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |