Change in baseline trough FEV1 · stable COPD
Triple therapy may leads to higher lung function, change in trough FEV1 (mL) compared with LABA/LAMA combination (low certainty).
1 finding from 1 review
Mortality (all‐cause) · stable COPD
Triple therapy may leads to lower mortality (all‐cause) compared with LABA/LAMA combination (low certainty).
1 finding from 1 review
All‐cause mortality (3‐week to 1‐year · Adults with COPD
Once‐daily LABA/LAMA in a combined inhaler showed no clear difference in all‐cause mortality (3‐week to 1‐year compared with placebo (low certainty).
1 finding from 1 review
Serious adverse events (3‐week to 1‐year · Adults with COPD
Once‐daily LABA/LAMA in a combined inhaler showed no clear difference in serious adverse events (3‐week to 1‐year compared with placebo (high certainty).
1 finding from 1 review
COPD exacerbations · Adults with COPD
Once‐daily LABA/LAMA in a combined inhaler probably leads to lower acute exacerbations of COPD (4‐week to 24‐week compared with placebo (moderate certainty).
1 finding from 1 review
SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · Adults with COPD
1 finding from 1 review
FEV1 · Adults with COPD
1 finding from 1 review
Difference vs placebo in adjusted peak FEV1 (3‐week to 6‐month · Adults with COPD
1 finding from 1 review
Adverse events (3‐week to 1‐year · Adults with COPD
Once‐daily LABA/LAMA in a combined inhaler showed no clear difference in adverse events (3‐week to 1‐year compared with placebo (high certainty).
1 finding from 1 review
Cough · people with acute cough or a clinical diagnosis of acute bronchitis
4 findings from 1 review
no estimate extracted
2 studies · 96 participants
Moderate
no estimate extracted
2 studies · 95 participants
Moderate
RR 0.89 [0.47, 1.68]
1 study · 59 participants
Moderate
Show 1 more finding
Tremor · people with acute cough or a clinical diagnosis of acute bronchitis
Beta‐2 agonists showed no clear difference in children: shaking or tremor recorded/reported by parents compared with placebo (moderate certainty).
1 finding from 1 review
Adults: night cough after seven days diary · people with acute cough or a clinical diagnosis of acute bronchitis
Beta‐2 agonists showed no clear difference in adults: night cough after seven days diary compared with placebo (moderate certainty).
1 finding from 1 review
Adults: shaking, tremor or nervousness diary · people with acute cough or a clinical diagnosis of acute bronchitis
Beta‐2 agonists may leads to higher adults: shaking, tremor or nervousness diary compared with placebo (low certainty).
1 finding from 1 review