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What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 50 findings · 5 reviews

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No studies found 21 · 42%GRADE not reported 0 · 0%Very low 19 · 38%Low 3 · 6%Moderate 3 · 6%High 4 · 8%

Baclofen vs placebo

Frequency of use % of heavy drinking days at the end of treatment · alcohol use disorder
1 finding from 1 review

Baclofen vs placebo

Adverse events: number of participants with ≥ 1 adverse event at end of treatment · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in adverse events: number of participants with ≥ 1 adverse event at end… compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropout · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts at end of treatment compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs placebo

Dropouts due to adverse events · alcohol use disorder

Summary of findings table ‐ Baclofen showed no clear difference in dropouts due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Baclofen vs acamprosate

Relapse: return to any drinking at end of treatment · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes relapse: return to any drinking at end of treatment compared with acamprosate (very low certainty).

1 finding from 1 review

Baclofen vs acamprosate

Adverse events as N of participants with at least one adverse event subjective and objective · alcohol use disorder

It is very uncertain whether summary of findings table ‐ Baclofen changes adverse events: number of participants with at least one adverse… compared with acamprosate (very low certainty).

1 finding from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: baclofen versus clonidine compared with other pharmacological detoxification treatment (very low certainty).

1 finding from 1 review