Findings

What do systematic reviews say?

43 questions · 44 findings · 8 reviews · Kidney and Transplant

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No studies found 4 · 9.1%GRADE not reported 0 · 0%Very low 3 · 6.8%Low 33 · 75%Moderate 4 · 9.1%High 0 · 0%

Metformin vs active control

UACR (% change) ( · preventing the progression of CKD

1 finding from 1 review

Metformin for preventing the progression of chronic kidney disease 2024 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 3836 participants
Low

Antibiotic prophylaxis vs placebo, no treatment or surveillance only

Number of participants with symptomatic UTI · primary VUR

Antibiotic prophylaxis showed no clear difference in symptomatic UTI; antibiotics versus placebo in trials with low risk… compared with surveillance or no treatment (moderate certainty).

1 finding from 1 review

Interventions for primary vesicoureteric reflux 2019 · Cochrane Headline outcomes only
RR 0.85 [0.4, 1.79]
3 studies · 943 participants
Moderate

DOAC vs variable dose warfarin

Intracranial haemorrhage · atrial fibrillation patients with CKD

Direct oral anticoagulants (DOAC) probably leads to lower intracranial haemorrhage compared with warfarin (moderate certainty).

1 finding from 1 review

Direct oral anticoagulants versus warfarin for preventing stroke and systemic embolic events among atrial fibrillation… 2017 · Cochrane Headline outcomes only
RR 0.43 [0.27, 0.69]
5 studies · 12521 participants
Moderate